Omics · study · 2026
Mechanosensing by endothelial Piezo1 promotes liver regeneration after partial hepatectomy via ATF2-ID1-Wnt2 pathway
Listed in NCBI GEO
In this present study we demonstrated portal hypertension after PHx promoted liver regeneration by activating mechanoreceptor Piezo1 in endothelial cells.
Description
Next, in vivo and in vitro experiment proved that Piezo1 activation in LESCs enhanced liver regeneration via Wnt2/β-catenin mediated LESCs-hepatocyte crosstalk: Shear stress-induced Piezo1 activation in LESCs promoted secretion of Wnt2 protein to the liver microenvironment via AFT2/ID1 signaling pathway, which further promoted the nuclear translocation of β-catenin in hepatocytes and consequently enhanced the proliferation of hepatocytes (Fig. 6M).
In addition, we confirmed the translational value of Piezo1 agonist Yoda1 in promoting liver regeneration after PHx.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298695 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298695 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1270968 ncbi.nlm.nih.gov/bioproject/PRJNA1270968 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE298695 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |