Data · dataset · 2026
Supplementary Figures S1-S6 from Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.1158/2159-8290.34040792
<p>Supplementary Fig. S1.
Description
ADAMTSL4 is enriched in conditioned media of cachexia-inducing cancer cell lines and is associated with systemic metabolic alterations in patients with cancer. Supplementary Fig. S2.
Overexpression of ADAMTSL4 converts non-cachexia-inducing cells into cachexia-inducing cells. Supplementary Fig. S3. Stable knockdown of ADAMTSL4 in cachexia-inducing cells attenuates their muscle-wasting capacity in vitro.
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Supplementary Fig. S4. Stable knockdown of ADAMTSL4 in cachexia-inducing tumor cells attenuates in vitro and in vivo adipocyte wasting and prolongs cachexia-related survival. Supplementary Fig. S5.
ADAMTSL4 targets LAP of latent TGF-β1 complex to promote myotube atrophy via TGF-β latency activation and TGFβR-dependent signaling. Supplementary Fig. S6. ADAMTSL4 induces wasting of murine and human white adipocytes via local activation of TGF-β1–TGFBR1 signaling, without altering circulating TGF-β1 levels.</p>
Links
Where it is published
- DOI doi.org/10.1158/2159-8290.34040792 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Cancer · Cancer · Cancer · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Oncology and carcinogenesis 72%
Provenance · 3 source records, 17 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34040792 | 11 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34040792 | 11 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34040792 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].anzsrc:group:3211 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |