Omics · study · 2026
High-altitude hypoxia suppresses triple-negative breast cancer growth by regulating ferroptosis via PHD2
Listed in NCBI GEO
High-altitude hypoxia may alter triple-negative breast cancer progression, but the underlying mechanisms remain incompletely understood.
Description
This study profiled transcriptomic changes in subcutaneous 4T1 tumors from female BALB/c mice maintained under ambient-altitude conditions in Lanzhou (approximately 1,500 m) or in a hypobaric chamber simulating an altitude of 3,500 m and treated with vehicle or the prolyl hydroxylase inhibitor IOX2.
RNA sequencing data from 12 tumors were analyzed to identify changes associated with altitude exposure and PHD inhibition. Differential expression and Kyoto Encyclopedia of Genes and Genomes analyses indicated ferroptosis-related transcriptomic alterations, supporting further evaluation of the SLC7A11-GSH-GPX4/ACSL4 axis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343905 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343905 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1513135 ncbi.nlm.nih.gov/bioproject/PRJNA1513135 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE343905 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |