Omics · study · 2026
Gene expression profiling of human DLD-1 cells after instant depletion of TREX2 subunits
Listed in NCBI GEO
We used the RNA-sequencing approach to distinguish the roles of TREX2 subunits in transcription, mRNA processing and RNA export.
Description
AID-mediated depletion of TREX2 subunits caused rapid changes in transcriptomic profiles and alternatively shaped cells’ transcriptomes. The transcriptomic changes associated with GANP and PCID2 loss appeared closely related.
Meanwhile, the loss of ENY2 produced a distinctly different transcriptomic profile compared to the loss of GANP and PCID2. The loss of CETNs had minimal impact on the cell transcriptome.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE291nnn/GSE291063 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291063 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1231485 ncbi.nlm.nih.gov/bioproject/PRJNA1231485 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Bioinformatics and computational biology 71%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE291063 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3102 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |