Omics · study · 2026
Reciprocal genetic screens identify epigenetics factors controlling epidermal cell activation. [RNAseq_FracNuclCytoProtr]
Listed in NCBI GEO
In adult tissues, in response to injury or to the acquisition of a mutational landscape, epithelial stem cells leave their homeostatic state and become activated.
Description
To identify the epigenetic factors involved in this process we performed pooled genetic screens integrated with two transcriptional read out systems. These revealed a network of factors including Kmt5c (Suv420h2), Ehmt2 and Cbx3.
Through a series of omics and cellular functional assays we discovered their functional role at the cellular and molecular level. In particular we identified a multi-layered control of gene expression, dependent by Cbx3, ranging from transcriptional regulation to mRNA localization.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE276nnn/GSE276627 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE276627 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1158254 ncbi.nlm.nih.gov/bioproject/PRJNA1158254 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Genetics 73%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE276627 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (73%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |