Omics · study · 2026
High Expression of TMEM161A in Colorectal Cancer is Associated with Tumor Proliferation and Poor Prognosis
Listed in NCBI GEO
TMEM161A is a membrane-associated protein implicated in oxidative stress responses, but its role in colorectal cancer (CRC) has not been elucidated.
Description
We analyzed 133 CRC specimens and found that high TMEM161A expression correlated with poor prognosis. siRNA-mediated TMEM161A knockdown in CRC cell lines (HT29, LIM1215) suppressed proliferation, colony formation, and invasion, with delayed G2/M transition. RNA-seq and GSEA revealed downregulation of E2F targets, G2/M checkpoint, MYC, and mTORC1 signaling, and upregulation of p53 and TNFα–NFκB pathways.
TMEM161A thus promotes CRC progression and may serve as a prognostic biomarker and therapeutic target.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309797 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309797 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1363198 ncbi.nlm.nih.gov/bioproject/PRJNA1363198 ↗
project · from NCBI GEO
- PubMed 42491763 pubmed.ncbi.nlm.nih.gov/42491763 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE309797 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |