Omics · study · 2026
Transcriptomic Profiling of Thyroid Eye Disease Orbital Fibroblasts
Listed in NCBI GEO
This project aims to define the persistent transcriptomic alterations in orbital fibroblasts (OFs) derived from patients with thyroid eye disease (TED) compared to non-TED OF controls.
Description
Primary OFs were isolated from orbital connective tissue and expanded in vitro under standardized conditions. We performed high-depth RNA sequencing on these cells to characterize the differential expression of genes involved in extracellular matrix remodeling, inflammatory signaling, and metabolic activation.
This dataset provides a comprehensive resource for identifying the molecular drivers of orbital remodeling in the context of TED.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329263 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329263 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1438758 ncbi.nlm.nih.gov/bioproject/PRJNA1438758 ↗
project · from NCBI GEO
- PubMed 42688036 pubmed.ncbi.nlm.nih.gov/42688036 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE329263 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |