Omics · study · 2026
Fibronectin mediates the interaction between vascular pathology and Alzheimer’s disease by inhibiting homeostatic gliovascular crosstalk
Listed in NCBI GEO
Alzheimer's disease (AD) often coexists with cerebrovascular pathology (CVP), contributing to cognitive decline and dementia.
Description
Understanding the molecular interplay between these pathologies is vital for developing effective therapies that can address the complexities of AD. The extracellular matrix (ECM) plays a crucial role in maintaining the blood-brain barrier (BBB) and modulating interactions of brain cell types with the vasculature.
Elevated levels of a particular ECM component, Fibronectin 1 (FN1) are associated with both AD and vascular dysfunctions. In this study we show the molecular regulation exerted by FN1 to regulate the homeostatic interaction between vasculature and the brain.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE268nnn/GSE268780 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE268780 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1118734 ncbi.nlm.nih.gov/bioproject/PRJNA1118734 ↗
project · from NCBI GEO
Topics
- Stated by source
- Danio rerio · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE268780 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:7955 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |