ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
A systems biology approach to dissect the hazardous effects of spaceflight and investigate induced torpor as a therapeutic countermeasureHumanities quest of interplanetary travel will present significant challenges, relating to crew nutrition, and the long-term exposure to microgravity and radiation, the effects of which have not been fully investigated. Chapter Three focuses on characterizing the response of fast (EDL) and slow (soleus) muscles to spaceflight (SF) which are known to be atrophy resistant (EDL) or atrophy prone (sol
ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Data and R code supporting “Integrating hatching, morphology, and behavior identifies complementary candidate indicators of early-life organismal state under biologically derived chemical environments in zebrafish”<p dir="ltr">This repository contains the raw data, processed data, statistical outputs, figures, model objects, and R scripts supporting the associated study on early-life zebrafish responses to ecologically relevant chemical cue environments.</p><p dir="ltr">Zebrafish embryos were exposed to seven cue-water treatments: control (C), conspecific-conditioned water (CC), non-predator heterospecific
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Discovering bioactive compounds for bone growth: the osteogenicity of marine organism-derived extractsThrough the current trend for bioprospecting, marine organisms - particularly algae - are becoming increasingly known for their osteogenic potential. Such organisms may provide novel treatment options for osteoporosis and other musculoskeletal conditions, helping to address their large healthcare burden and the limitations of current therapies. This study focused on screening for marine-organism d
ZivaHub2026 · dataset
Polystyrene Nanoplastics Disrupt Lateral Line Neuromasts and Impair Flow-Guided Behaviors in ZebrafishNanoplastics (NPs) are pervasive aquatic pollutants; however, their effects on fish mechanosensory function remain poorly understood. This study investigated the impacts of polystyrene NPs (PS-NPs) on the lateral line system of zebrafish (<i>Danio rerio</i>) across life stages by integrating hydrodynamic behavioral assays with cellular, ultrastructural, transcriptomic, and protein-level analyses.
Borealis2026 · Microscopy · unknown
Function aligns with geometry in locally connected neuronal networksData associated with the "Function aligns with geometry in locally connected neuronal networks" paper.
ZivaHub + HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Single-cell RNA sequencing
Single-cell transcriptomic profiling of zebrafish pectoral fins during androgen-induced breeding tubercle formation<p dir="ltr">This project investigates the cellular composition and transcriptional changes associated with androgen-induced breeding tubercle formation in zebrafish (Danio rerio) pectoral fins. Six-month-old female zebrafish were exposed to 0.5 μM 11-ketotestosterone (11-KT) or DMSO vehicle control for 14 days. Pectoral fin tissues were collected and dissociated into single-cell suspensions for s
NCBI GEO2026 · Methylation profiling by high throughput sequencing · 10 samples
Sublethal Fipronil and Cyfluthrin Exposure Induces Locus-Specific DNA Hypomethylation at Stress, Immune, and Xenobiotic-Response Genes in Adult ZebrafishAquatic organisms are exposed to pesticide residues that can lead to non-lethal molecular effects. This study investigated DNA methylation at toxicologically relevant loci in adult zebrafish. Fish were exposed to low and high concentrations of each compound for 7 days under semi-static conditions. We performed targeted bisulfite amplicon sequencing at six loci representing stress response (hsp70.1
NCBI GEO2026 · Methylation profiling by high throughput sequencing · 4 samples
Epigenetic Disordering Drives Stemness, Senescence Escape and Tumor Heterogeneity [WGBS]Tumor heterogeneity is the substrate for tumor evolution and the linchpin of treatment resistance. The widespread epigenome repatterning that characterizes most cancers can generate cells with diverse identities and malignant features; however, how this occurs is not known. We show that high levels of the epigenetic regulator and oncogene UHRF1 in zebrafish hepatocytes rapidly induce disordering o
NCBI GEO2026 · RNA sequencing · 13 samples
Blood Flow-Mediated Biomechanical Activation of Yap/Taz-Driven Transcriptional Regulation of Self-renewal Programs Controls Developmental Hematopoietic Stem Cell ExpansionMechanical forces from blood flow are essential for production of hematopoietic stem and progenitor cells (HSPCs) during embryogenesis, but the molecular mechanisms by which hemodynamic cues are sensed and orchestrate endothelial-to-hematopoietic (EHT) transition remain incompletely defined. In this study, we employed 10x Genomics scRNAseq to characterize the transcriptomic changes in Kdrl+ hemato
NCBI GEO2026 · RNA sequencing · 4 samples
Hippo signalling regulates Meox1 to control venous sprouting and lymphangiogenesisDuring development, lymphatic vessels are generated when a small number of lymphatic progenitors invade growing tissues and form a new vasculature. The Hippo pathway, which regulates organ growth and cell fate control, is essential for lymphatic development. Nevertheless, the downstream target genes and mechanisms involved remain to be identified. Here, by analysing yap1 mutant vasculature with si
NCBI GEO2026 · RNA sequencing · 6 samples
Hippo signalling regulates transitory Meox1 control of venous cell adhesion and sprouting during lymphatic vascular developmentThis SuperSeries is composed of the SubSeries listed below.
NCBI GEO2026 · Genome binding/occupancy profiling by high throughput sequencing · 2 samples
Hippo signalling regulates transitory Meox1 control of venous cell adhesion and sprouting during lymphatic vascular development [snATAC-Seq]During vertebrate development, the lymphatic vasculature first emerges by cellular sprouting from pre-existing embryonic veins. A small number of lymphatic progenitors sprout out from the walls of functional blood vessels and invade growing tissues to generate an entirely new vasculature. The regulation of this process at a cellular and molecular level, remains to be fully understood. The Hippo pa
NCBI GEO2026 · RNA sequencing · 6 samples
Transient activation of potent progenitor cells is required for spinal cord regenerationAdult zebrafish exhibit full recovery following spinal cord injury. Transient sox2 upregulation and expansion of sox2+ progenitors are thought to underlie their regenerative capacity. Here, we determined the molecular identities, stem cell properties, and contributions of sox2+ progenitors during spinal cord repair. Genetic lineage tracing shows zebrafish spinal progenitors, while quiescent in uni
NCBI GEO2026 · RNA sequencing · 1 samples
Cellular composition of zebrafish spleen melanomacrophage centresAntibody affinity maturation in mammals occurs in germinal centers (GCs), supported by follicular dendritic cells (FDCs) and T follicular helper (Tfh) cells. Teleost fish lack GCs, and their melanomacrophage centres (MMCs) have been proposed as functional analogues; however, the presence of FDCs remains uncertain. To define MMC cellular composition, we isolated autofluorescent MMCs from zebrafish
NCBI GEO2026 · RNA sequencing · 8 samples
Altered lipid metabolism contributes to cytopenia and myeloid expansion in parn-mutant dyskeratosis congenitaGermline mutations in the PARN gene cause dyskeratosis congenita, an inherited bone marrow failure syndrome (IBMFS) characterized by multilineage cytopenia and progression to myeloid disease. The mechanisms underlying this malignant transformation have not been fully elucidated. Using a loss-of-function zebrafish parn mutant generated through CRISPR-Cas9 editing, we found expanded myeloid progenit
NCBI GEO2026 · RNA sequencing · 48 samples
Kainate receptors couple primitive hematopoiesis to Notch-dependent HSPC emergence by shaping hemogenic niche cellular architectureThe establishment of lifelong hematopoiesis depends on a transient, instructive embryonic niche that enables hematopoietic stem and progenitor cell (HSPC) emergence from hemogenic endothelium. We identify a requirement for kainate receptors (KARs), a class of glutamate-gated ion channels, in primitive hematopoiesis and hemogenic niche organization, which together support Notch-dependent HSPC emerg
figshare2026 · Astronomical catalogue
Table 4_Sublethal cadmium exposure disrupts cardiac function and tissue structure in zebrafish larvae.pdf<p>Cadmium remains a primary toxicological concern because it does not degrade and easily enters the food chain, affecting diverse ecosystems. This study aimed to evaluate the effects of sublethal cadmium exposure on cardiac function and on brain and heart tissues in zebrafish (Danio rerio) larvae, utilizing photoplethysmography as a rapid, non-invasive approach. Larvae (1 day post-hatching) were
figshare2026 · Astronomical catalogue
Table 3_Sublethal cadmium exposure disrupts cardiac function and tissue structure in zebrafish larvae.pdf<p>Cadmium remains a primary toxicological concern because it does not degrade and easily enters the food chain, affecting diverse ecosystems. This study aimed to evaluate the effects of sublethal cadmium exposure on cardiac function and on brain and heart tissues in zebrafish (Danio rerio) larvae, utilizing photoplethysmography as a rapid, non-invasive approach. Larvae (1 day post-hatching) were
figshare + Loughborough Research Repository2026 · Astronomical catalogue
<p>GO enrichment of gene subsets: U-Ut, U-St, U-hSt, S-Ut, S-St, S-hSt, hS-Ut, hS-St, and hS-hSt.</p><p>GO enrichment of gene subsets: U-Ut, U-St, U-hSt, S-Ut, S-St, S-hSt, hS-Ut, hS-St, and hS-hSt.</p>
figshare2026 · Astronomical catalogue
Table 5_Sublethal cadmium exposure disrupts cardiac function and tissue structure in zebrafish larvae.pdf<p>Cadmium remains a primary toxicological concern because it does not degrade and easily enters the food chain, affecting diverse ecosystems. This study aimed to evaluate the effects of sublethal cadmium exposure on cardiac function and on brain and heart tissues in zebrafish (Danio rerio) larvae, utilizing photoplethysmography as a rapid, non-invasive approach. Larvae (1 day post-hatching) were
figshare + Loughborough Research Repository2026 · Astronomical catalogue
<p>GO enrichment analyses of gene subsets defined by maximal expression stage and phyletic age.</p><p>Subsets of ancient U genes (phyletic age > 4,290 million years) with peak expression at stages 10.3, 16, 19, and 24 hpf, and subsets of young S and hS genes (phyletic age < 600 million years) with peak expression at stages 5.25 and 6 hpf were included.</p> <p>(XLSX)</p>
figshare + Loughborough Research Repository2026 · Astronomical catalogue
<p>Enrichment of anatomical terms from ZFIN for U, S, and hS genes.</p><p>Enrichment of anatomical terms from ZFIN for U, S, and hS genes.</p>
NCBI GEO2026 · RNA sequencing · 6 samples
Novel regulators of zebrafish glomerular developmentPodocyte cell differentiation in coordination with specialized endothelial cells forms the glomerulus, the kidney blood filter. Genetic analysis of animal models and human affected individuals has identified over 50 susceptibility genes that, when mutated, cause filtration defects or proteinuria. To explore the potential for new genetic pathways or components in glomerular development, we generate
figshare2026 · Astronomical catalogue
Table 7_Sublethal cadmium exposure disrupts cardiac function and tissue structure in zebrafish larvae.pdf<p>Cadmium remains a primary toxicological concern because it does not degrade and easily enters the food chain, affecting diverse ecosystems. This study aimed to evaluate the effects of sublethal cadmium exposure on cardiac function and on brain and heart tissues in zebrafish (Danio rerio) larvae, utilizing photoplethysmography as a rapid, non-invasive approach. Larvae (1 day post-hatching) were
figshare2026 · Astronomical catalogue
Table 2_Sublethal cadmium exposure disrupts cardiac function and tissue structure in zebrafish larvae.pdf<p>Cadmium remains a primary toxicological concern because it does not degrade and easily enters the food chain, affecting diverse ecosystems. This study aimed to evaluate the effects of sublethal cadmium exposure on cardiac function and on brain and heart tissues in zebrafish (Danio rerio) larvae, utilizing photoplethysmography as a rapid, non-invasive approach. Larvae (1 day post-hatching) were