Table · dataset · 2026
Table 1_Case Report: Simultaneous stereotactic re-irradiation using HyperArc for 44 brain metastases after whole-brain radiotherapy.docx
Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.3389/fonc.2026.1949603.s001
Background<p>Treatment options for disseminated intracranial recurrence after whole-brain radiotherapy (WBRT) are limited.
Description
Repeat WBRT offers modest efficacy and may worsen neurocognitive function. Modern single-isocenter techniques such as HyperArc may enable efficient stereotactic radiotherapy (SRT) of numerous brain metastases.</p>Case presentation<p>A 62-year-old man with extensive-stage small-cell lung cancer and more than 40 brain metastases received systemic therapy followed by WBRT with 30 Gy in 10 fractions, resulting in near-complete intracranial regression.
Approximately ten months later, magnetic resonance imaging revealed 41 new lesions and progression of 3 previously detected metastases. Because of his excellent performance status, all 44 lesions were treated with fractionated HyperArc SRT using 21.0 Gy in 3 fractions. Standardized neurocognitive testing was performed before SRT and repeated after 4 and 12 weeks.
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It demonstrated only selective deterioration without global or subjectively relevant impairment. Follow-up imaging after subsequent initiation of tarlatamab showed marked regression after 4 weeks and near-complete response after 3 months. Two additional lesions were subsequently treated with SRT, followed 7 months later by a second HyperArc course for 8 new metastases.
At last follow-up, no treated lesion had locally recurred, and no radiographic radionecrosis was observed.</p>Conclusion<p>Fractionated single-isocenter HyperArc SRT may represent a feasible salvage option for carefully selected patients with extensive intracranial recurrence after WBRT. The observed local control and limited neurocognitive deterioration support further prospective evaluation of this approach.</p>
Links
Where it is published
- DOI doi.org/10.3389/fonc.2026.1949603.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Humanities · Humanities · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science
- Inferred from text
- Cancer 75% · Imaging 75% · Magnetic resonance imaging 75% · Oncology and carcinogenesis 69% · Tabular 65%
Provenance · 2 source records, 33 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33979348 | 10 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/33979348 | 10 d ago | JSON v1 |
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| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
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| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
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| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |