TOX sustains the longevity and multipotency of CD4 Tprog cells during chronic LCMV infection

Although considerable attention has been given to progenitor CD8 T cells, the distinct biological roles and multiple fates of CD4 T cells raise questions about the molecular circuitry controlling CD4 Tprog in settings of chronic stimulation. Here, we interrogated the impact of the HMG-box transcription factor (TF) TOX on the developmental flexibility of virus-specific CD4 T cells and the role of this TF in coordinating the transcriptional and epigenetic program of CD4 Tprog during chronic infection.

These studies revealed key elements of CD4 Tprog biology that are central to sustaining T cell responses to persistent infection. First, TOX was dispensable for CD4 Tprog development but required for maintenance and function of these cells over time. Second, TOX promoted CD4 Tprog maintenance and survival by regulating expression of BIM and BCL-2.