Data · dataset · 2026
Lifestyle factors, medications and colon cancer survival stratified by biomarkers: a molecular cancer epidemiology approach
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32633481.v1
Colorectal cancer (CRC) has a complex multi-mechanistic and multi-factorial aetiology, with different tumours having distinct genomic and epigenomic alterations.
Description
Tumours with similar characteristics, on the other hand, can be classified together due to their presumed common development mechanism. Traditionally this classification has been solely on the basis of tumour morphology.
Molecular understanding of CRC has improved significantly in recent years, culminating in a proposed consensus molecular classification of CRC, but we still do not fully comprehend the interactions between molecular biomarkers, commonly used medications, and lifestyle factors on survival outcomes. <br><br>For these reasons, the overall aim of this thesis was to examine how specific molecular and immune biomarkers, and exposures (including commonly used medications, lifestyle factors) interact to influence survival of colon cancer patients within a large population-based cohort.In summary, subgroups of patients who are tobacco smokers appear to have poorer prognosis according to their molecular characteristics; the evidence is less consistent for alcohol use.
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Preliminary evidence for deleterious association between ARB use and patients with MSS status tumours requires further investigate to optimise patient safety and outcomes. A large resource has been created to enable future transcriptional biomarker studies that would also address a major gap in molecular pathology epidemiology (MPE) cancer studies. Such clarification of molecular and immune specific associations between lifestyle factors, medications and CRC survival would help to inform analysis strategies for ongoing trials in this subject and would also guide the design of targeted stratified trials in the future.<br><i><br><br></i>
Links
Where it is published
- DOI doi.org/10.17034/32633481.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Cancer 75% · Oncology and carcinogenesis 74%
Provenance · 4 source records, 18 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32633481 | 11 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32633481 | 11 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32633481 | 11 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32633481 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3211 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (74%) |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |