Excel · study · 2026
Analysis of lysyl oxidase family in pancreatic cancer progression using syngeneic orthotopic inoculation model
Listed in NCBI GEO
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, and no effective cure exists yet.
Description
Identifying molecular targets for this cancer is an urgent priority. To mimic the pancreatic tumor microenvironment, we utilized a mouse pancreatic orthotopic inoculation model with murine pancreatic cancer cells Panc02.
New derivatives, named Panc02-3P cells, were established through 3 cycles of serial transplantations. These cells exhibited increased tumor-forming and high metastatic ability both in vitro and in vivo. RNA-sequence analysis revealed that Panc02-3P cells acquired a mesenchymal phenotype through the induction of epithelial-mesenchymal transition (EMT), compared to parental Panc02 cells, despite unaltered expression of EMT-related transcriptional factors.
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We also found that members of lysyl oxidase (LOX) family including LOX, LOXL1 and LOXL3, were highly expressed in Panc02-3P cells. Loss of function assays using siRNAs targeting LOX and LOXL1 demonstrated that invasive ability of Panc02-3P cells was attenuated by LOX and LOXL1 suppression. This study suggests that the LOX family could play a pro-tumor role and serve as potential therapeutic targets in pancreatic cancer.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314975 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314975 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1393359 ncbi.nlm.nih.gov/bioproject/PRJNA1393359 ↗
project · from NCBI GEO
- PubMed 42298507 pubmed.ncbi.nlm.nih.gov/42298507 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE314975 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |