Omics · study · 2026
High-Throughput Screening of Cancer Cluster Metastasis Inhibitors [Human]
Listed in NCBI GEO
Extravasation is a pivotal step in cancer metastasis, however, no molecular control of cancer extravasation has yet been achieved because the mechanism behind this process remain poorly understood.
Description
Here, we identify Bay 61-3606 as cancer extravasation inhibitor using high throughput drug screening. Bay 61-3606 significantly decreases cancer cluster extravasation, which is associated with higher metastasis potential, in a zebrafish model.
This inhibitory effect extends to decreased distant metastasis in a murine lung carcinoma model and a triple-negative breast cancer model. In addition, our RNA-sequencing results reveal the essential role of COL8A1, a cell-adhesion related molecule expressed by the extravasation participating endothelial cells, in cancer cluster extravasation. Bay 61-3606 treatment effectively decreases COL8A1 through JNK signaling pathway, resulting in impaired cancer cluster extravasation.
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As the infiltration of immune cells is independent on COL8A1, our findings suggest Bay 61-3606 is a potent drug for anti-metastasis therapy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE243nnn/GSE243084 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE243084 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1016337 ncbi.nlm.nih.gov/bioproject/PRJNA1016337 ↗
project · from NCBI GEO
- PubMed 42616881 pubmed.ncbi.nlm.nih.gov/42616881 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE243084 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |