Omics · study · 2026
RNA-Seq analysis SIRT6 or KDM5C knockdown effect on pancreatic cancer cell line
Listed in NCBI GEO
Description
Pancreatic cancer is among the deadliest malignant tumours, characterized by rapid progression, poor prognosis, and high mortality.SIRT6 and KDM5C plays an important role in tumorigenesis, development, and drug resistance .However, the precise molecular mechanisms through which SIRT6 and KDM5C inhibit tumorigenesis and metastasis in pancreatic cancer, as well as its role in cancer stem cells (CSCs), remain unclear.Collectively, our findings identify SIRT6 and KDM5C as key regulators of pancreatic cancer progression and suggest that they represent potential targets for early diagnosis and therapeutic intervention.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315634 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315634 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1398363 ncbi.nlm.nih.gov/bioproject/PRJNA1398363 ↗
project · from NCBI GEO
- PubMed 41998659 pubmed.ncbi.nlm.nih.gov/41998659 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE315634 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |