LRMDA suppresses colonic inflammation, colorectal cancer and bacterial infection [CRC_RNA-seq]

Here, we show that LRMDA expression is downregulated in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and in colorectal tumor tissues. Similarly, we demonstrate that LRMDA deficiency exacerbates dextran sulfate sodium (DSS)-induced colitis, promotes tumorigenesis in azoxymethane (AOM)/DSS and AOM/Vil-Cre;Trp53fl/fl (VP) models and aggravates enteric pathogen infection.

Mechanistically, LRMDA may positively regulate the normal exocytosis of mucins from intestinal goblet cells into the intestinal lumen via the dynein-dynactin-microtubule pathway by interacting with the ICD domain of DCTN1. These findings identify LRMDA as a novel regulator of intestinal mucosal barrier function.