Omics · study · 2026
PPARγ-Mediated Ferroptosis in Macrophages Enhances Persistent Pulmonary Infction by Mycobacterium tuberculosis
Listed in NCBI GEO
In this study, we found that Mycobacterium tuberculosis (Mtb) uses the PPARγ-GPX4 axis to induce ferroptosis in host cells, promoting persistent infection.
Description
Elevated PPARγ levels in macrophages post-Mtb infection, due to direct interactions with Mtb IDH and impaired degradation, lead to suppressed GPX4 expression and increased lipid peroxidation. Deleting PPARγ reduces lung inflammation, Mtb burden, and restores GPX4 expression in infected macrophages.
This discovery of Mtb hijacking PPARγ to induce ferroptosis suggests a promising target for tuberculosis treatment.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE275nnn/GSE275146 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE275146 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1149689 ncbi.nlm.nih.gov/bioproject/PRJNA1149689 ↗
project · from NCBI GEO
- PubMed 42259813 pubmed.ncbi.nlm.nih.gov/42259813 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE275146 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |