A Compendium of Cancer Organoid Models for Diverse Cancer Type

However, existing model collections do not yet represent the full spectrum of diversity observed in human cancer. Recent technologies enable more efficient model derivation (e.g., tumor organoids), yet whether such models maintain the molecular states of the originating tumor in long term ex vivo expansion has not been systematically investigated.

Here, we present the results of a large-scale international program—the Human Cancer Models Initiative (HCMI)—including 665 patient-derived models from tumors provided by 2,594 donors. The collection enables tumor/model comparisons by whole genome, exome, methylome and transcriptome analyses. It includes 522 models with comprehensive clinical data, 153 models of rare cancers, and 71 models derived from non-European populations.