Omics · study · 2026
Chromatin accessibility profiling of wild-type and Slc31a1 conditional knockout mouse bone marrow stromal cells by ATAC-seq
Listed in NCBI GEO
Age-associated bone loss is largely driven by impaired osteoblast generation from bone marrow stromal cells (BMSCs), but the metabolic and epigenetic mechanisms that constrain osteogenic commitment remain incompletely understood.
Description
This study identifies SLC31A1-mediated copper uptake as a cell-intrinsic metabolic checkpoint required for BMSC osteogenic differentiation and skeletal integrity. ATAC-seq was performed to profile genome-wide chromatin accessibility in wild-type and Slc31a1 conditional knockout mouse BMSCs.
The analysis revealed altered chromatin accessibility in Slc31a1-deficient BMSCs, including increased accessibility at the Id1 locus, supporting a model in which copper-dependent mitochondrial metabolism epigenetically restrain Id1 expression to permit osteogenic commitment.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337266 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337266 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1484604 ncbi.nlm.nih.gov/bioproject/PRJNA1484604 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE337266 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |