Excel · study · 2026
Microwave therapy for the treatment of cutaneous melanoma metastases
Listed in NCBI GEO
The management of recurrent skin melanoma is often challenging due to acquired or primary resistance to immunotherapy; for many patients additionally, surgical excision of recurrence is unsuitable.
Description
This study evaluated a potential efficacy of microwave treatment for cutaneous melanoma metastases by comparing pre- and post-treatment changes over three weeks. RNA sequencing of tissue with HTG EdgeSeq system’s Precision Immuno-Oncology Panel (PIP) was undertaken from all samples.
All treated metastases reduced in size following microwave therapy. Twenty five percent of participants showed an improvement in Dermatology Life Quality Index scores. RNA sequencing data revealed downregulated cancer-related markers in complete responders compared to partial responders.
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These findings provide evidence supporting the efficacy of microwave ablation for the treatment of advanced cutaneous melanoma.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE279nnn/GSE279418 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE279418 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1172676 ncbi.nlm.nih.gov/bioproject/PRJNA1172676 ↗
project · from NCBI GEO
- PubMed 42316430 pubmed.ncbi.nlm.nih.gov/42316430 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE279418 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |