Omics · study · 2026
Deletion of endothelial glycocalyx component endomucin impairs retinal vascularization and suppresses pathological neovascularization
Listed in NCBI GEO
Endomucin (EMCN), an endothelial-selective glycocalyx component highly expressed in capillaries and venous endothelium, plays a critical role in regulating vascular endothelial growth factor receptor 2 (VEGFR2) endocytosis and downstream of VEGF signaling.
Description
Using a global EMCN knockout mouse model, we investigated the effects of EMCN deficiency on retinal vascularization during development and pathological angiogenesis.
While Emcn-/- mice showed no significant difference in the avascular area in an oxygen-induced retinopathy (OIR) model, there was a significant reduction in neovascular tufts at postnatal day 17. RNA seq of the OIR retinas with gene ontology enrichment analysis indicate response to hypoxia and angiogenesis pathways were differentially regulated in Emcn-/- mice in OIR.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE288nnn/GSE288833 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE288833 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1219573 ncbi.nlm.nih.gov/bioproject/PRJNA1219573 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE288833 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |