Omics · study · 2026
Dissecting the cell autonomous and non-autonomous chromatin alterations upon DNMT1 deletion in PV interneurons
Listed in NCBI GEO
The maturation of cortical networks relies on the precise coordination between excitatory neurons and inhibitory interneurons, whose disruptions underlie the pathophysiology of several neuropsychiatric disorders.
Description
Parvalbumin-expressing (PV) interneurons play a key role in modulating cortical excitability and synchronization, making them central to a stable network and proper cognitive function. To better understand the contribution of epigenetic regulation in these processes, we examined the role of DNA methyltransferase 1 (DNMT1) in PV interneurons.
By selectively depleting DNMT1 in this population, we aimed to unravel how the absence of DNMT1 impacts the chromatin landscape and, through this, neuronal function, network activity, and mechanisms underlying neuropsychiatric dysfunction.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE341nnn/GSE341363 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341363 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1501423 ncbi.nlm.nih.gov/bioproject/PRJNA1501423 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 70%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE341363 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |