Omics · study · 2026
microRNA profiling to identify the biological pathways potentially associated with the actions of IVIg treatment
Listed in NCBI GEO
Purpose: Our study has demonstrated favorable effects of intravenous immunoglobin (IVIg) treatment on acute neurological status, motor function, anxiety level, and spatial learning ability after severe TBI in a controlled cortical impact (CCI) mouse model.
Description
We conducted high throughput small RNA-Seq to identify the biological pathways potentially associated with the actions of IVIg treatment.
Methods
Read the rest (2 more)
Differentially expressed (DE) miRNAs were identified using pairwise comparisons: a. TBI vs. sham, b. TBI-IVIg vs sham, and c.
TBI vs TBI-IVIg (n =8 each treatment group), from brain samples and plasma samples collected 48 hours after TBI. Small RNAs were sequenced with 51 bp single-end reads using Illumina HiSeq 4000 and read quality was assessed using FastQC.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE276nnn/GSE276381 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE276381 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1156805 ncbi.nlm.nih.gov/bioproject/PRJNA1156805 ↗
project · from NCBI GEO
Topics
- Stated by source
- Mus musculus · Non-coding RNA profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE276381 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |