Text · study · 2026
Transcriptional profiling of the effects of HDAC4 or HDAC5 knockdown in uveal melanoma cell lines with monosomy of chromosome 3 (M3) and BAP1 mutations or disomy of chromosome 3 (D3) and wild-type BAP1
Listed in NCBI GEO
Monosomy of chromosome 3 (M3) and mutations in BAP1 are strongly associated with metastatic risk in uveal melanoma.
Description
We aimed to investigate the roles of HDAC4 and HDAC5 in uveal melanoma cell lines with differential status of chromosome 3 and BAP1. We compared gene expression after shRNA knockdown of HDAC4 or HDAC5, respectively, in two uveal melanoma cell lines with monosomy of chromosome 3 (M3) and BAP1 mutations and two uveal melanoma cell lines with disomy of chromosome 3 (D3) and wild-type BAP1.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE199nnn/GSE199470 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE199470 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA820046 ncbi.nlm.nih.gov/bioproject/PRJNA820046 ↗
project · from NCBI GEO
- PubMed 42773415 pubmed.ncbi.nlm.nih.gov/42773415 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Genetics 70%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE199470 | 7 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |