Data · study · 2026
Expression Data from murine follicular B cells with or without Kindlin-3 knockout
Listed in NCBI GEO
Integrin-mediated interactions between hematopoietic cells and their microenvironment are important for the development and function of immune cells.
Description
Here, we studied the role of the integrin adaptor Kindlin-3 in B cell homeostasis. To this end, we compared B cell development in B cell specific knockout mice for Kindlin-3 with that in wt littermates.
In the spleen, constitutive B cell specific Kindlin-3 knockout caused a loss of marginal zone B cells but expansion of follicular B cells. To gain further insight on the mechanisms behind this expansion we performed microarray analysis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE172nnn/GSE172080 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE172080 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA721965 ncbi.nlm.nih.gov/bioproject/PRJNA721965 ↗
project · from NCBI GEO
- PubMed 34888947 pubmed.ncbi.nlm.nih.gov/34888947 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 71%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE172080 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |