Omics · study · 2026
Prenatal stress reprograms placental signaling and opposes maternal immune activation effects in the fetal brain
Listed in NCBI GEO
Prenatal psychosocial stress and maternal immune activation are associated with offspring psychiatric risk, but their effects on the placenta and fetal brain may involve shared or distinct transcriptional programs.
Description
This dataset profiles matched whole mouse placentas and whole fetal brains after prenatal restraint stress and a maternal poly(I:C) challenge. Placental bulk RNA-seq showed an attenuated antiviral transcriptional response to poly(I:C) after prenatal stress.
Fetal-brain co-expression analyses identified overlapping DNA-repair, synaptic, and translational networks regulated in opposing directions by prenatal stress and maternal immune activation. Cross-tissue analyses assessed associations between placental antiviral gene-expression modules and fetal-brain networks.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347619 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347619 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1530618 ncbi.nlm.nih.gov/bioproject/PRJNA1530618 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE347619 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |