ATRX loss predicts poor outcomes and reveals a therapeutic vulnerability to TEAD inhibition in soft tissue sarcomas -- ATAC

Loss of ATRX is associated with aggressive tumor behavior, but the chromatin regulatory mechanisms underlying ATRX-deficient sarcomas remain incompletely understood. In this study, we investigated changes in chromatin accessibility associated with ATRX loss in sarcoma models.

We performed ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) to characterize genome-wide accessible chromatin landscapes in ATRX-deficient and control sarcoma cells. Our analyses identified widespread alterations in chromatin accessibility and chromatin de-repression following ATRX loss, with differential accessible regions enriched for transcription factor motifs. These ATAC-seq data provide genome-wide profiles of accessible chromatin and support investigation of ATRX-dependent regulatory elements and transcriptional programs in sarcoma.