Transcript landscape in the heart of inducible cardiomyocyte-specific Immt knockout mice

The MICOS complex plays pivotal roles for crisa juction formation and connection of inner mitochondrial membrane and outer mitocondrial membrane of mitochondria. Although it is well known that the ristae are crucial for energy production by OXPHOS, it is still precisely unknown how the Mic60 is important in the adult matured cardiomyocytes in vivo.

To expand our knowledge about the Mic60 functions in the adult mouse heart, we utilized inducible cardiomyocyte-specific Immt gene knockout mice and conducted bulk RNA-seq with the hearts. Our data highlights the mitochondria stress response at transcript level in the hearts.