Tumor-associated Macrophage GnT-V Enhances Sensitivity to Antitumor Immunotherapy through Branched N-Glycosylation to Promote M1 Polarization

Immunotherapy based on immune checkpoint inhibitors (ICIs) has become one of the most successful clinical treatment strategies and has marked a milestone in the field of cancer therapy.

Regrettably, the complex immunosuppressive network within the tumor microenvironment (TME), characterized by imbalanced immune cell subsets and suppressed immune cell function, represents a major cause of ICI treatment failure. This study, through single-cell analysis, provides mechanistic insights into TAM polarization and establishes the therapeutic feasibility of targeting this regulatory axis, thereby introducing a novel treatment strategy to benefit cancer patients.