Text · study · 2026
Microarray analysis of E14.5 embryonic bladder urothelium following conditional Tbx2/Tbx3 loss
Listed in NCBI GEO
The T-box transcription factors Tbx2 and Tbx3 play critical roles in tissue patterning and organogenesis, but their specific function in bladder epithelial development remains poorly understood.
Description
In this study, we investigated the transcriptional changes occurring in the embryonic bladder urothelium following the deletion or reduction of Tbx2 and/or Tbx3 in epithelial progenitors. We isolated GFP-positive urothelial cells from E14.5 embryos using fluorescence-activated cell sorting (FACS) from pooled mutant and control genotypes.
Total RNA was analyzed by microarray hybridization to identify downstream target genes and molecular pathways regulated by Tbx2/3 during early bladder development.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE341nnn/GSE341339 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341339 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1501371 ncbi.nlm.nih.gov/bioproject/PRJNA1501371 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE341339 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |