Omics · study · 2026
Effects of circAASS overexpression in human HK2 cells
Listed in NCBI GEO
The mechanism underlying circRNA-mediated maintenance of mitochondrial function remains largely unknown.
Description
Our study found circAASS was downregulated in renal cortex from mice suffered ischemic reperfusion (IR)-induced acute kidney injury (AKI). Functional study demonstrated that circAASS regulated mitochondrial homeostasis in tubular epithelial cells (TECs).
Therefore, to reveal the mechanisms underlying the anti-injury effects of circAASS in TECs. circAASS was overexpressed in hypoxia/reperfusion treated- human immortalized cell line HK2 cells. RNA sequencing was performed and the dysregulated mRNAs were found.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE286nnn/GSE286356 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE286356 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1208969 ncbi.nlm.nih.gov/bioproject/PRJNA1208969 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE286356 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |