RNASeq dataset of human chondrocytes treated with caspase-1 and -8 inhibitors under osteoarthritis-like conditions

Inflammation and cell death are two key events in OA and also key canonical functions of caspases. Since caspases play an important role in modulating inflammation, caspase inhibitors have been widely utilized to study diseases involving inflammation in animal models and clinical trials.

Among these, key caspases, which are responsible for activation of the corresponding pathways include caspase-8 for the receptor mediated apoptotic pathway and caspase-1 as the key inflammatory caspase being involved in OA pathogenesis. OA- and non-OA chondrocytes were treated with caspase-1 and -8 inhibitors and TNFa. RNA was isolated after 3 days and processed for RNA sequencing.