Investigating the role and mechanisms of key epigenetic modulators in endothelial cell specification and function

<div>Understanding the key mechanisms of differentiating vascular cell from induced pluripotent stem cells (iPSCs) is crucial for maximising the success of establishing novel therapies in treating diseases such as ischaemia, myocardial infarction and peripheral arterial disease as the ability to create functional, safe, and rejuvenated vascular cells could have significant therapeutic implications.</div><div>This thesis reveals novel transcriptional and epigenetic mechanisms of endothelial cells (ECs) derived from iPSCs, mediated by the regulation of SET Similar Protein (SETSIP) and SET Domain Containing 7, Histone Lysine Methyltransferase (SETD7/ SET7), respectively.</div><div>The identification of these new regulators for the differentiation of iPSCs into vascular cells is a major advance in the field of regenerative medicine.

This breakthrough paves the way for the development of more effective and efficient therapies that can be translated into clinical applications, using small molecules and growth factors to generate well-defined protocols.</div><div><i>Thesis is embargoed until 31 July 2028.</i></div>