NCL Data2026 · dataset
Supplementary file 1_Metabolic memory in diabetic complications: evidence for persistent cellular states and limits of therapeutic reversal.docx<p>Metabolic memory is defined here as an exposure-history-dependent cellular phenotype that persists beyond immediate carry-over after verified withdrawal of the initiating exposure, principally high glucose and is accompanied by a specified functional impairment or an altered response to the same defined secondary stimulus. This operational definition separates cellular memory from clinical lega
NCL Data2026 · dataset
HiC and Capture-HiC data<p dir="ltr">Pioneer transcription factors specify cell identity by targeting silent chromatin and initiating lineage-specific programming, yet their roles in human erythropoiesis remain incompletely defined. Here, through integrated multi-omics analysis, we identify TAL1 as a bona fide pioneer transcription factor that coordinates a multi-layered chromatin remodeling program essential for erythro
NCL Data2026 · dataset
Environmental circadian disruption alters rhythmicity of clock and epigenetic gene expression in SKH-1 female mouse livers<p>Endogenous circadian rhythms are primarily entrained by environmental cues that are used to regulate the function of cells and peripheral tissues throughout the body. We found that disrupted light schedules – reflective of shift work conditions – demonstrated impaired gene expression throughout the 24-h day in core clock and epigenetically regulated genes. Dysregulated expression in these genes
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown
Supplementary Table S2 from ALKBH5 in Cancer-Associated Fibroblasts Governs an Epitranscriptomic Axis That Drives Pancreatic Cancer Metastasis<p>List of antibodies used in this study</p>
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown
Table S3 from Targeting p300 Reverses Acidic Microenvironment–Induced PARP Inhibitor Resistance<p>Table S3</p>
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown
Supplementary Table S1 from ALKBH5 in Cancer-Associated Fibroblasts Governs an Epitranscriptomic Axis That Drives Pancreatic Cancer Metastasis<p>Table S1A. Basic clinicopathological information of fibroblast donors;Table S1B. Independent fibroblast lines used in each experiment;Table S1C. Basic clinicalpathological information of PDAC patients in the TMA cohort;Table S1D. Basic clinicopathological information of non-TMA PDAC cases</p>
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown
Table S4 from Targeting p300 Reverses Acidic Microenvironment–Induced PARP Inhibitor Resistance<p>Table S4</p>
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown
Table S1 from Targeting p300 Reverses Acidic Microenvironment–Induced PARP Inhibitor Resistance<p>Table S1</p>
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown
Supplementary Table S3 from ALKBH5 in Cancer-Associated Fibroblasts Governs an Epitranscriptomic Axis That Drives Pancreatic Cancer Metastasis<p>S3A. List of siRNAs used in this study;S3B. List of shRNAs and overexpression constructs used in this study;S3C. List of sgRNAs used in this study;S3D. List of plasmids used in this study</p>
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown
Supplementary Table S5 from ALKBH5 in Cancer-Associated Fibroblasts Governs an Epitranscriptomic Axis That Drives Pancreatic Cancer Metastasis<p>S5A. Sequencing information of m6A-seq (CON and ATRA groups);S5B. Sequencing information of m6A-seq (SC and A5-KD groups);S5C. Sequencing information of RIP-seq</p>
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown
Table S2 from Targeting p300 Reverses Acidic Microenvironment–Induced PARP Inhibitor Resistance<p>Table S2</p>
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown
Supplementary Table S4 from ALKBH5 in Cancer-Associated Fibroblasts Governs an Epitranscriptomic Axis That Drives Pancreatic Cancer Metastasis<p>List of primers used in this study</p>
ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset · unknown
HDAC inhibition results in suppression of FOXM1 and genes associated with poor prognosis prostate cancer through p53 dependent and independent mechanismsProstate cancer is a disease of remarkable biological heterogeneity and is now the most commonly diagnosed malignancy in men worldwide. The standard of care combination of ADT and radiotherapy is highly effective in patients with locally advanced prostate cancer yet a third of patients relapse within 3 years. Therefore, strategies to treat or prevent development of ADT/radiotherapy-refractory dise
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset
Investigating the role and mechanisms of key epigenetic modulators in endothelial cell specification and function<div>Understanding the key mechanisms of differentiating vascular cell from induced pluripotent stem cells (iPSCs) is crucial for maximising the success of establishing novel therapies in treating diseases such as ischaemia, myocardial infarction and peripheral arterial disease as the ability to create functional, safe, and rejuvenated vascular cells could have significant therapeutic implications
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset
Aberrant DNA methylation remodelling as a critical determinant of endothelial colony-forming cell angiogenic dysfunction in experimental hypoxia.Objective: Cord blood-derived endothelial colony-forming cells (CB-ECFCs) are a valuable source for vascular repair with low immunogenicity provided their angiogenic potential can be effectively harnessed to combat harsh ischaemic conditions. Recent studies show that DNA methylation regulates endothelial cell angiogenic dysfunction under cardiovascular stress. We aimed to 1) investigate impact of
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset
Investigating the role of SWI/SNF in malignant peripheral nerve sheath tumoursMalignant peripheral nerve sheath tumours (MPNST) are rare and aggressive soft tissue sarcomas that are typically therapy resistant. Mutations of genes involved in the polycomb repressive complex 2 (PRC2), an important modulator of transcriptional repression, occur in up to 75% of MPNST cases. In normal cells, PRC2 has an antagonistic regulatory relationship with the SWI/SNF epigenetic regulating
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset
Molecular profiling of urban environmental impacts: understanding the biology underlying environmental stress and identifying biomarkers of resilience to cognitive impairment and neurodegenerative diseasesThe burden of neurodegenerative disease has devastating impacts on the health and quality of life of the ageing population. It is integral that research and policy take a focus on reducing neurodegenerative disease occurrence and progression through preventative research and strategy. The outdoor environment is home to a multitude of features and factors which can contribute to neurodegenerative d
ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset · unknown
The impact of chronic loss of STAG2 on DNA damage repair and the epigenome in acute myeloid leukaemiaAcute myeloid leukaemia (AML) is a genetically heterogeneous disease characterised by the expansion of immature blast cells in the bone marrow and it primarily affects individuals aged 65 and over. Through next generation sequencing studies, the genetic landscape of AML has become increasingly better characterised leading to the identification of recurrent gene mutations. Cohesin complex genes wer
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset
Elucidating the role of CHD4 as a chromatin and epigenetic modifier in acute myeloid leukaemiaAcute Myeloid Leukaemia (AML) are an array of blood cell disorders arising from alterations within myeloid precursors. The NuRD complex controls nucleosome assembly and chromatin accessibility; CHD4 is a core subunit involved in a multitude of functions including epigenetic regulation, DNA replication and repair and cell cycle progression. However, little is known about the molecular function of C
UCL Research Data Repository2026 · dataset · unknown
Probing the role of histone acetylation in the evolution of pathogenicity in <i>Candida glabrata</i>With the advancement of modern medicine, invasive fungal infections are a growing cause of global mortality.<i> Candida glabrata</i> accounts for 25% of fungal infections in UK hospitals, second only to<i> C. albicans</i>. This number is expected to rise given current treatment challenges due to the former’s intrinsic antifungal resistance. <i>C. glabrata </i>also possesses a particularly interest
ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset · unknown
Ontology-led molecular classification of colorectal cancer uncovers distinct tumour subtypes with therapeutic and clinical relevanceColorectal cancer (CRC) is a multifaceted and heterogeneous disease. The molecular profiling of CRC has made it possible to detect tumours with unique biological features. Gene expression-based signatures have been at the forefront of cancer research in providing valuable prognostic and predictive information. However, these published signatures rarely make any clinical impact.<br><br>This thesis
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset
Investigating BTK inhibition-related epigenetic mechanisms and the role of TRIM24 ni CD5+ malignant B cellsBTK inhibition (BTKi) by ibrutinib (IB) represents a significant advancement in treating CD5+'B cell malignancies like Chronic Lymphocvtic Leukemia (CLL) and Mantle Cell Lymphoma (MCL). Recent studies indicate that BTKimodifies epigenomic and transcriptomic dynamics in CLL, prompting us to explore these effects globally and at a gene-specific level. We sequenced a matched CLL sample (pre- and post
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Uncovering the molecular circuitries of deleted in oral cancer 1 (DOC1) in oral squamous cell carcinomas (OSCC)Oral squamous cell carcinomas (OSCCs) are the most common type of malignancy affecting the oral cavity, characterised by formation and invasion of squamous cell islands deep to the surface epithelium. Tumour resection is the first line of treatment for early stages of OSCC. However, OSCC is often detected in later stages at which point adjuvant radiotherapy and/or chemotherapy are required. Curren
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset
Molecular mechanisms of NMC plasticity and fate commitmentElongation of the anteroposterior (AP) axis in vertebrates relies on a pool of stem cell-like Neuromesodermal competent cells (NMCs) that supply the neural tube and paraxial mesoderm with progenitors during embryogenesis. A finely tuned balance between NMC self-renewal and commitment to neural or mesodermal fates governs NMC homeostasis. This balance is orchestrated by converging Wnt, FGF and reti
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Unravelling key regulators of cell fate changes during epithelial-mesenchymal transitionTumour metastasis is considered as a significant challenge to patient survival, meanwhile epithelial to mesenchymal transition (EMT) as a key driver of tumour aggressiveness. Understanding the mechanisms underlying EMT regulation is crucial for developing effective strategies to prevent further cancer cell metastasis. While many transcription factors and histone regulators have been identified as