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Omics · study · 2026

Neural Circuit Dysfunction in SAH Mice: Targeting PSAP for Therapeutic Intervention in Consciousness Disorders

Listed in NCBI GEO

Description

We have employed a single-nucleus RNA sequencing approach to investigate the neural circuit mechanisms of consciousness disorders after subarachnoid hemorrhage (SAH), focusing on the regulatory role of the Psap/Gpr axis in oligodendrocytes on CL-mPFC circuit conduction and white matter integrity, and validate potential therapeutic intervention.

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Expression profiling by high throughput sequencing · Mus musculus
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Life Sciences
Inferred from text
RNA sequencing 75% · Sequencing 75% · Zoology 71%
Provenance · 1 source records, 10 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE29580512 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].anzsrc:group:3109enrichment · NCBI GEOtaxonomy-embedding@1.1.0title+keywords+description (71%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title