Excel · study · 2026
Cytoplasmic ATM restricts oncolytic VSVΔ51 replication by sustaining TBK1-IRF3 signaling in glioblastoma cells
Listed in NCBI GEO
ATM is a nuclear DNA damage response kinase with tumor-suppressive functions, but its cytoplasmic function during virus infection remains poorly understood.
Description
Here, we identify cytoplasmic ATM as an antiviral factor that restricts oncolytic virus (OVs) replication. Infection with oncolytic VSVΔ51 triggered CRM1-dependent nuclear export of ATM, generating cytoplasmic ATM that associated with viral dsRNA-containing complexes.
Blocking ATM nuclear export or inhibiting ATM attenuated type I interferon induction, thereby licensing viral replication. Mechanistically, cytoplasmic ATM interacted with the ubiquitin-like domain of TBK1 and sustained TBK1-IRF3 signaling. ATM inhibition potentiated oncolytic cytotoxicity and promoted immunogenic cell death in cancer cells.
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In multiple tumor models, pharmacological inhibition or genetic loss of ATM cooperated with VSVΔ51 to suppress tumor growth, prolong survival of mice, and promote durable antitumor immunity. These findings reveal the cytoplasmic function of ATM in antiviral innate immunity and identify it as a therapeutic vulnerability for improving oncolytic virotherapy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342072 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342072 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1505557 ncbi.nlm.nih.gov/bioproject/PRJNA1505557 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE342072 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |