The role of Nuclear factor NF-Y in nutrient-mediated tissue turnover

The intestinal turnover relies on dietary cues, mediated by nutrient-sensing pathways, to regulate the balance between cell division and cell death. Several signaling pathways, including the target of rapamycin (mTOR), are known to play a role in this process.

However, specific mechanisms of how nutrient-sensing pathways adjust intestinal turnover remain unclear. My unpublished results show that silencing of NF-Y in ISCs disrupts cellular turnover, cell adhesion, and cell communication, leading to excessive cell delamination into the intestinal lumen and the development of dysplastic changes in the intestinal epithelium. mRNA sequencing from ISCs shows that NF-Y regulates several genes related to the activity of the nutrient-sensing mTOR pathway.