Omics · study · 2026
Cutaneous nonpeptidergic neurons sense extracellular ATP to augment barrier repair and C. albicans host defense
Listed in NCBI GEO
Cutaneous pain-sensing nociceptive neurons can directly recognize pathogen invasion and modulate the resulting host immune response.
Description
Nociceptor recognition of C. albicans cell wall components is necessary and sufficient for optimal protective local Type-17 immune responses. We now report a parallel neuroimmune pathway in which extracellular ATP (eATP) released from C. albicans and keratinocytes activates nonpeptidergic neurons including Mrgprd-expressing NP1 neurons through the P2RX3 ATP receptor.
Ablation of NP1 neuron or P2rx3 increased C. albicans CFU but the induction of Type-17 responses was unaffected. Rather, transcriptomic analysis revealed alteration in genes and pathways associated with barrier repair. P2rx3-/- mice showed increased wound size and transepidermal water loss associated with a delay in barrier repair following C. albicans infection or abrasion.
Read the rest (1 more)
These data reveal a novel pathway where nonpeptidergic neurons sense epidermal damage or infection through eATP and P2X3 resulting in augmented barrier repair and host defense.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329413 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329413 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1458817 ncbi.nlm.nih.gov/bioproject/PRJNA1458817 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE329413 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |