Static magnetic field ameliorates hepatic injury via Piezo1 as a magneto-mechanical effector

Here, we demonstrate that SMF exposure significantly attenuates liver injury across acute, subacute, and chronic models, as evidenced by reduced serum aminotransferase levels, diminished hepatocellular necrosis, and decreased collagen deposition.

Mechanistically, SMF promotes hepatocyte survival by enhancing mitochondrial respiration rather than by stimulating cell proliferation, as evidenced by increased oxygen consumption rate, ATP production, and mitochondrial membrane potential. Multi-omics analyses revealed metabolic reprogramming centered the tricarboxylic acid cycle and identified malate dehydrogenase 1 (MDH1) as a key metabolic effector. We identify Piezo1 as a key magneto-mechanical through which SMF-induced Ca²⁺ signaling enhances MDH1 enzymatic activity and mitochondrial respiratory capacity.