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Excel · study · 2026

Tension-Induced Osteogenesis in periodontal ligament stem cells

Listed in NCBI GEO

Orthodontic tooth movement (OTM) relies on alveolar bone remodeling governed by periodontal ligament stem cells (PDLSCs).

Description

The mechanotransduction pathways linking mechanical tension to osteogenesis remain unknown. PIEZO1 is a mechanosensitive cation channel that plays a pivotal role in cell function regulation and fate determination.

In this study, PIEZO1 knockdown and RNA sequencing were performed to reveal the mechanism of tension-induced osteogenesis.

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Topics

Stated by source
Expression profiling by high throughput sequencing · Homo sapiens
From keywords
Life Sciences
Inferred from text
RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE31290010 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title