Omics · study · 2026
Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in human lung adenocarcinoma
Listed in NCBI GEO
We have employed a single cell sequencing approach using 10x Genomics scRNAseq and scTCR-seq to study the heterogeneity and molecular architecture of tumor microenvironment (TME) caused by BRCA1 and BRCA2 somatic mutations in lung adenocarcinoma (LUAD).
Description
LUADs are considered to be a heterogeneity population in the lung epithelium. Homologous recombination repair (HRR) deficiency has been linked to enhanced immunotherapy responses in non-small cell lung cancer patients.
The HRR genes BRCA1 and BRCA2 are key regulators of DNA repair, yet their impact on the TME in LUAD remains unclear.This study provides a comprehensive characterization of the BRCA-mutant TME in LUAD patients, uncovering distinct immune response mechanisms and potential therapeutic strategies. These findings enhance our understanding of BRCA1/2-driven molecular architecture and offer novel insights into improving therapy efficacy in LUAD.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE292nnn/GSE292700 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292700 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1240965 ncbi.nlm.nih.gov/bioproject/PRJNA1240965 ↗
project · from NCBI GEO
- PubMed 42189716 pubmed.ncbi.nlm.nih.gov/42189716 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · Genetics 72% · Sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE292700 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |