Table · study · 2026
Hepatic and Brain Spatial Gene Expression Changes in Intragastric Alcohol Fed APP/PS1 Alzheimer's Disease Mouse Model
Listed in NCBI GEO
Chronic alcohol consumption is an emerging risk factor for Alzheimer’s disease (AD), potentially through liver–brain crosstalk.
Description
To assess how alcohol-induced liver injury influences AD-related brain changes, spatial transcriptomic profiling was performed in 32-week-old male APP/PS1 mice after 5 weeks of intragastric ethanol or control diet. Using the NanoString GeoMx Digital Spatial Profiler, this study profiled plaque-bearing and plaque-free hippocampal and cortical regions of interest, along with periportal and perivenous liver regions.
Differential gene expression and pathway analyses identified shared and tissue-specific molecular changes, as well as candidate therapeutic targets that may link alcohol-related liver injury to AD-associated brain pathology.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324193 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324193 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1433583 ncbi.nlm.nih.gov/bioproject/PRJNA1433583 ↗
project · from NCBI GEO
- PubMed 42687927 pubmed.ncbi.nlm.nih.gov/42687927 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Mus musculus · Other
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE324193 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |