Omics · study · 2026
RNA-seq profiling of SOX10 overexpression in TADA2B KO A375 melanoma cells
Listed in NCBI GEO
SOX10 is a key regulator of melanoma lineage identity, and TADA2B is a component of the SAGA histone acetyltransferase complex.
Description
To investigate the transcriptional interplay between SOX10 and TADA2B, bulk RNA sequencing (RNA-seq) was performed in control and TADA2B KO A375 melanoma cells with and without SOX10 overexpression. This dataset enables comparative analysis of gene expression programs associated with SOX10 activation, loss of TADA2B, and their combined perturbation, providing a resource to examine how SAGA-dependent epigenetic regulation influences melanoma transcriptional states.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319449 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319449 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1423302 ncbi.nlm.nih.gov/bioproject/PRJNA1423302 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319449 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |