Data · dataset · 2026
Figure S1: Proteomic changes in treated Myh-GRK2 KO mice
Listed in ZivaHub and Deakin Research Online — shown once because both records carry DOI 10.6084/m9.figshare.33477136.v1
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Description
Background
Radiation-induced heart disease (RIHD) is a complication of radiotherapy, caused by mitochondrial dysfunction and oxidative stress. G protein-coupled receptor kinase 2 (GRK2), beyond its typical role in G protein-coupled receptors (GPCRs) desensitization, has been linked to mitochondrial dynamics and cardiomyocyte health.
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Methods
We studied the effects of IR exposure in cardiomyocyte-specific GRK2 knockout (Myh-GRK2 KO) mice compared to GRK2 fl/fl (CTR) at 3h and 24h post-IR. GRK2 deficiency worsens IR-induced cardiac dysfunction at 3h post-exposure, persisting at 24h. Results: Proteomic analysis showed that GRK2 deficiency impairs the expression of mitochondrial proteins basally.
TEM showed a reduction in mitochondrial number, increased swelling, and an altered structure in Myh-GRK2 KO mice. Importantly, GRK2 deficiency impaired activation of the PINK1/Parkin/DRP1 mitophagy axis, while increasing LC3 and decreasing p62 levels. In CTR mice, GRK2 moved to mitochondria post-IR, supporting mitochondrial integrity.
Conclusion: GRK2 is essential for mitochondrial integrity during IR stress; its absence induces mitochondrial alterations, impairs mitophagy, and leads to cardiac dysfunction, identifying GRK2 as a therapeutic target.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.33477136.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Medicine & Health · Medicine & Health
- Inferred from text
- Cardiovascular disease 65% · Disease 75% · Heart 75% · Oncology and carcinogenesis 69%
Provenance · 2 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/33477136 | 12 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/33477136 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:cardiovascular-disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3211 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |