Omics · study · 2026
Transcriptomic analysis of colchicine effects in adenine-induced chronic kidney disease
Listed in NCBI GEO
Colchicine is an anti-inflammatory drug that has emerged as a therapeutic option in various inflammatory diseases, but its role in chronic kidney disease (CKD) remains unclear.
Description
This study investigates the reno-protective effects of colchicine in an experimental CKD model and its potential role in modulating the NOD-like receptor, pyrin domain containing protein 3 (NLRP3) inflammasome pathway. A CKD animal model was established in C57BL/6 mice by feeding a 2% adenine-containing diet for 4 weeks.
Mice received either colchicine (0.3 mg/kg/day) or saline intraperitoneally. RNA sequencing of kidney tissue was performed by E-Biogen Inc. (Seoul, Korea) to capture molecular signatures associated with the therapeutic mechanism of colchicine in CKD, with a focus on inflammatory pathways including nuclear factor-κB and NLRP3 pathways.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318367 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318367 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1418636 ncbi.nlm.nih.gov/bioproject/PRJNA1418636 ↗
project · from NCBI GEO
- PubMed 42237213 pubmed.ncbi.nlm.nih.gov/42237213 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE318367 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |