Omics · study · 2026
Assay for Transposase-Accessible Chromatin With High-Throughput Sequencing in Mouse BMDMs Following CD74 Deficiency
Listed in NCBI GEO
We employed ACAT-Seq technology to perform a genome-wide assessment of chromatin accessibility changes following CD74 knockout in mouse bone marrow-derived macrophages (BMDMs), with a focus on alterations in regulatory elements associated with aerobic glycolysis-related genes.
Description
On this basis, we further explored the potential molecular mechanisms by which CD74 regulates the aerobic glycolytic metabolic pathway in macrophages, including its impact on the accessibility of key transcription factor binding sites and the activity of associated signaling pathways.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328037 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328037 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1453539 ncbi.nlm.nih.gov/bioproject/PRJNA1453539 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328037 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |