Omics · study · 2026
Benzo[a]pyrene-induced AHR activation in human ESCs primes premature neurogenesis in cerebral organoids
Listed in NCBI GEO
Benzo[a]pyrene (BaP) is a widespread polycyclic aromatic hydrocarbon and environmental contaminant with potential adverse effects on early development.
Description
To investigate the transcriptional response of human pluripotent stem cells to BaP exposure, H9 human embryonic stem cells were exposed to 1 μM BaP for 7 days. Transcriptomic changes following BaP exposure were subsequently assessed by bulk RNA sequencing.
This dataset provides a resource for investigating the molecular responses and potential mechanisms associate with BaP exposure during the pluripotent stage of human development.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346007 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346007 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1522725 ncbi.nlm.nih.gov/bioproject/PRJNA1522725 ↗
project · from NCBI GEO
- PubMed 42667716 pubmed.ncbi.nlm.nih.gov/42667716 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE346007 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |