RNA-seq based correlation analysis of producer cell and STV-C8

Comprehensive RNA profiling demonstrated that STVs package predominantly the intended therapeutic RNA while strongly minimizing the incorporation of endogenous cellular transcripts, highlighting the ability of engineered RNA-protein interactions to direct selective cargo loading.

This highly defined RNA composition underpins the robust delivery performance of STVs, enabling efficient transfer of diverse functional RNAs, including mRNAs encoding transcription factors, gene editors, and antiviral effectors, across multiple cell types and in vivo models.