Data Sheet 1_Effects of long-term inhaled corticosteroids on growth velocity and adult height in children with asthma: a systematic review and meta-analysis.docx

In the primary random-effects meta-analysis, ICS treatment was associated with a non-significant reduction in linear growth velocity compared with controls (MD, −0.38 cm/year; 95% CI, −0.84 to 0.07; I² = 64%). After excluding studies judged to be at high risk of bias, the pooled estimate became statistically significant (MD, −0.59 cm/year; 95% CI, −1.10 to −0.07), suggesting a possible small reduction in linear growth velocity rather than definitive evidence of an effect.

A reduction was observed in school-age children (MD, −0.50 cm/year; 95% CI, −0.96 to −0.04), although age-specific differences remained uncertain. Limited long-term evidence suggested a small reduction in adult height (MD, −1.20 cm; 95% CI, −1.90 to −0.50).</p>Conclusion<p>In the primary analysis, long-term maintenance ICS therapy did not demonstrate a statistically significant reduction in linear growth velocity in children with asthma.

However, sensitivity analysis excluding studies at high risk of bias suggested a possible small reduction. Evidence regarding adult height was limited and derived predominantly from one long-term follow-up study. These findings should therefore be interpreted cautiously and balanced against the established benefits of ICS for asthma control.</p>