Table 1_Association between sleep and ovarian reserve in women undergoing IVF/ICSI: a Mendelian randomization and cross-sectional study.docx

Clinical cross-sectional analyses showed that advanced age (≥35 years, OR: 1.14, 95% CI: 1.07–1.21), unemployment (OR: 0.61, 95% CI: 0.40–0.91), primary infertility (OR: 0.57, 95% CI: 0.35–0.92), sleep disturbance (OR: 2.42, 95% CI: 1.39–4.21), and shorter sleep duration (OR: 1.89, 95% CI: 1.27–2.80) were associated with diminished ovarian reserve (DOR). After adjusting for age, employment status, and infertility type, short sleep duration (6–7 hours and <7 hours) and sleep disturbances remained significantly associated with elevated FSH levels, reduced AMH (Anti-Müllerian hormone) levels, and decreased AFC (antral follicle count).

Among women aged <35 years, both short sleep duration and poor sleep quality were significantly associated with DOR. In women aged ≥35 years, only poor sleep quality—not short sleep duration—was significantly associated with DOR.</p>Conclusion<p>Shorter sleep duration (<7 hours/night) was associated with DOR in women undergoing IVF/ICSI, particularly in those aged <35 years. In contrast, poor sleep quality adversely affected ovarian reserve regardless of age.</p>